Document Details
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Document Type |
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Thesis |
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Document Title |
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SERUM HEAVY METALS, OXIDIZED LOW DENSITY LIPOPROTEINS AND ANTIOXIDANT VITAMINS LEVELS AS RISK FACTORS FOR CORONARY ARTERY DISEASES IN HYPERTENSIVE PATIENTS مستويات المعادن الثقيلة، البروتين الدهني منخفض الكثافة المؤكسد والفيتامينات المضادة للأكسدة في مصل الدم كعامل خطورة لأمراض الشريان التاجي في مرضى ضغط الدم المرتفع |
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Subject |
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Faculty of Sciences |
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Document Language |
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Arabic |
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Abstract |
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Background: Hypertension (HTN) is a major risk factor for Cardiovascular Diseases (CVD). The chronic exposure to CVD risk factor will cause oxidative stress (OS) which is free radical and reactive oxygen species (ROS) formation. The role of OS in CVD is mostly due to endothelial dysfunction, reduction in the production of nitric oxide (NO) and low density lipoprotein cholesterol (LDL-c) oxidation. All of these will enhance the progression of atherosclerosis and CVD. One of the less recognized causes of CVD is heavy metals toxicity from our environment.
Throughout this study we have focused on the oxidative hypothesis in atherosclerosis in human, and the role of some heavy metals toxicity in hypertensive patients as a risk factor for coronary artery disease.
Objective: The aim of the present study was to evaluate the levels of Lipid profile (serum cholesterol, triglycerides, HDL, and LDL), serum oxidized LDL concentration, heavy metals concentration such as: [Cadmium (Cd), Cobalt (Co), Chromium (Cr), Copper (Cu), and Lead (Pb)], and serum Malondialdehyde (MDA) and its significant as early prediction of Coronary Artery Diseases (CAD) in hypertensive patients.
Methods: The study was conducted on ninety subjects, they were divided into three groups (thirty samples each) as following: Control Group (Group I), Patients with HTN (Group II) and Patients with HTN and CAD (Group III). Venous blood samples (5ml) were obtained from all fasted patients and controls. for 12-14 hours.
Results obtained showed that serum levels of HDL-cholesterol in patients of HTN and HTN with CAD had a significant lowering, while total cholesterol, Triacylglycerol and LDL-cholesterol were significantly elevated, in both groups, as compared with control group (P < 0.05 for each).
There were no significant changes in serum Cd concentration in both groups (patients with HTN and HTN with CAD) as compared with control group.
For rest elements, (Co, Cr, Cu and Pb), patients with HTN and HTN with CAD had a significant elevation (P < 0.05) in serum concentration of these metals as compared with control group.
Oxidized LDL level in the samples of patients with HTN and HTN with CVD had a significant elevation (P < 0.05) as compared with control group.
In the TBA test reaction for determination of TBARS level (MDA), there is a very high significant elevation of MDA concentration in the samples of Group II, and there is no significant changes of MDA concentration in the samples of Group III as compared with control Group.
It is concluded that there is a positive correlation (r=0.6) between oxidative stress and atherosclerosis. Also there is an association between heavy metals contamination and CVD (r = 0.05). |
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Supervisor |
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Mazen Abdul Hadi Zamzami |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1438 AH
2016 AD |
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Added Date |
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Thursday, December 22, 2016 |
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Researchers
| لينه يوسف الجنادي | ALJANADI, LINA YOSOUF | Researcher | Master | |
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